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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MKNK1
All Species:
17.88
Human Site:
S437
Identified Species:
35.76
UniProt:
Q9BUB5
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9BUB5
NP_001129025.1
465
51342
S437
G
L
C
S
M
K
L
S
P
P
C
K
S
R
L
Chimpanzee
Pan troglodytes
XP_001162271
453
49967
S425
G
L
C
S
M
K
L
S
P
P
C
K
S
R
L
Rhesus Macaque
Macaca mulatta
XP_001098645
414
46209
R390
L
S
P
P
C
K
S
R
L
A
R
R
R
A
Q
Dog
Lupus familis
XP_539626
415
46182
L391
S
P
P
C
K
S
R
L
A
R
R
R
A
L
A
Cat
Felis silvestris
Mouse
Mus musculus
O08605
427
47896
L403
S
P
P
S
K
S
R
L
A
R
R
R
A
L
A
Rat
Rattus norvegicus
Q4G050
413
46195
S389
K
L
S
P
P
S
K
S
R
L
A
R
R
R
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001235171
508
56331
S478
A
V
C
S
M
K
L
S
P
P
C
K
S
R
L
Frog
Xenopus laevis
Q9YGW0
418
46898
R394
K
S
R
L
A
K
R
R
A
Q
A
H
A
R
K
Zebra Danio
Brachydanio rerio
NP_001108211
459
51123
S434
D
F
G
A
V
V
C
S
M
R
L
S
P
P
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651986
1142
128445
T953
Q
V
P
Q
R
Q
H
T
E
N
W
R
Y
R
T
Honey Bee
Apis mellifera
XP_395927
516
58135
S483
L
H
Q
L
F
G
L
S
P
P
S
E
S
R
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_779905
511
56921
S484
G
L
N
N
F
G
L
S
P
P
G
Q
S
A
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96.7
87.9
82.8
N.A.
85.3
82.3
N.A.
N.A.
51.5
72
68.3
N.A.
20.3
46.1
N.A.
37.7
Protein Similarity:
100
96.7
88.1
85.8
N.A.
88.5
85.3
N.A.
N.A.
63.3
79.7
76.7
N.A.
28.2
63.1
N.A.
52.4
P-Site Identity:
100
100
6.6
0
N.A.
6.6
20
N.A.
N.A.
86.6
13.3
6.6
N.A.
6.6
46.6
N.A.
53.3
P-Site Similarity:
100
100
13.3
13.3
N.A.
20
26.6
N.A.
N.A.
93.3
20
20
N.A.
33.3
53.3
N.A.
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
9
9
0
0
0
25
9
17
0
25
17
25
% A
% Cys:
0
0
25
9
9
0
9
0
0
0
25
0
0
0
0
% C
% Asp:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
9
0
0
9
0
0
0
% E
% Phe:
0
9
0
0
17
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
25
0
9
0
0
17
0
0
0
0
9
0
0
0
0
% G
% His:
0
9
0
0
0
0
9
0
0
0
0
9
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
17
0
0
0
17
42
9
0
0
0
0
25
0
0
9
% K
% Leu:
17
34
0
17
0
0
42
17
9
9
9
0
0
17
42
% L
% Met:
0
0
0
0
25
0
0
0
9
0
0
0
0
0
0
% M
% Asn:
0
0
9
9
0
0
0
0
0
9
0
0
0
0
0
% N
% Pro:
0
17
34
17
9
0
0
0
42
42
0
0
9
9
0
% P
% Gln:
9
0
9
9
0
9
0
0
0
9
0
9
0
0
9
% Q
% Arg:
0
0
9
0
9
0
25
17
9
25
25
42
17
59
0
% R
% Ser:
17
17
9
34
0
25
9
59
0
0
9
9
42
0
9
% S
% Thr:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
9
% T
% Val:
0
17
0
0
9
9
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _